In Vitro Cell Culture Models of Hyperoxaluric States: Calcium Oxalate and Renal Epithelial Cell Interactions

Urolithiasis is a multifactorial disease with high incidence and recurrence rate, characterized by formation of solid deposits in the urinary tract. The most common type these stones are calcium oxalate stones. Calcium crystals can, hyperoxaluric states, interact renal epithelial cells, causing injury to epithelia. Pathogenesis urolithiasis widely investigated, but underlying mechanisms still not completely clarified. In vitro models offer insight into molecular processes which lead stone significant for evaluation prophylactic therapeutic management patients urolithiasis. this review, we summarize recently published data from studies investigating interactions cell lines, anti-urolithiatic mechanisms, results exploring possible options cultures.